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Bile acid glycine and taurine conjugates in serum of patients with primary biliary cirrhosis: effect of ursodeoxycholic treatment.

✍ Scribed by Chretien, Y; Poupon, R; Gherardt, M F; Chazouilleres, O; Labbe, D; Myara, A; Trivin, F


Book ID
126881371
Publisher
BMJ Publishing Group
Year
1989
Tongue
English
Weight
808 KB
Volume
30
Category
Article
ISSN
0017-5749

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Bile acid composition in fasting duodenal bile was assessed at entry and at 2 years in patients with primary biliary cirrhosis (PBC) enrolled in a randomized, doubleblind, placebo-controlled trial of ursodeoxycholic acid (UDCA) (10-12 mg/kg/d) taken as a single bedtime dose. Specimens were analyzed

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We have compared the effect of ursodeoxycholic acid with placebo on the clinical state, blood liver chemistries and serum and urinary bile acids in four patients with primary biliary cirrhosis. All parameters were evaluated monthly, and bile acid composition was measured by capillary gas-liquid chro