Bile acid conjugation in early stage cholestatic liver disease before and during treatment with ursodeoxycholic acid
โ Scribed by Mario Fracchia; Kenneth D.R. Setchell; Andrea Crosignani; Mauro Podda; Nancy O'Connell; Roberto Ferraris; Alan F. Hofmann; Giovanni Galatola
- Book ID
- 115828346
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 632 KB
- Volume
- 248
- Category
- Article
- ISSN
- 0009-8981
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๐ SIMILAR VOLUMES
Beneficial effects of ursodeoxycholic acid in chronic cholestatic liver diseases have been attributed to displacement of hydrophobic bile acids from the endogenous bile acid pool. To test this hypothesis, we determined pool sizes, fractional turnover rates, synthesis/input rates and serum levels of
We have previously documented that ursodeoxycholic acid exerts a beneficial effect on liver function and bile acid metabolism in patients with cystic fi- brosis. We hypothesized that the mechanism of action may be related in part to the choleretic properties of the administered bile acid. We therefo