𝔖 Bobbio Scriptorium
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Bile acid biosynthesis

✍ Scribed by Mosbach, Erwin H. ;Salen, Gerald


Book ID
112476636
Publisher
Springer-Verlag
Year
1974
Weight
662 KB
Volume
19
Category
Article
ISSN
0002-9211

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We have generated a line of mutant mouse that lacks ␀Klotho, a protein that structurally resembles Klotho. The synthesis and excretion of bile acids were found to be dramatically elevated in these mutants, and the expression of 2 key bile acid synthase genes, cholesterol 7␣-hydroxylase (Cyp7a1) and