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Bile acid absorption in isolated bile duct units (IBDU) is primarily due to the apical bile acid transporter

โœ Scribed by Alpini, Gianfranco; Glaser, Shannon; Phinizy, Jo Lynne; Hofmann, Alan F.; LeSage, Gene


Book ID
122078556
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
199 KB
Volume
118
Category
Article
ISSN
0016-5085

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Secretin activation of the apical Na+-de
โœ Gianfranco Alpini; Shannon Glaser; Leonardo Baiocchi; Heather Francis; Xuefeng X ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 439 KB

The role of the cholangiocyte apical Na ุ‰ -dependent bile acid transporter (ASBT) in bile formation is unknown. Bile acid absorption by bile ducts results in cholehepatic shunting, a pathway that amplifies the canalicular osmotic effects of bile acids. We tested in isolated cholangiocytes if secreti