Bildung von 2-(1-Methyl-1, 4, 5, 6-tetrahydropyridyl-3)-2-oxazolin-4-on aus 1-Methyl-1, 4, 5, 6-tetrahydronicotinsäureamid und Bromessigsäureäthylester und seine Überführung in O-(1-Methylnipecotinoyl)glykolsäureamid via das dazu tautomere Cyclol

✍ Scribed by Franz Troxler

• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: German
• Weight: 225 KB
• Volume: 56
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19730560545

✦ Synopsis

Abstract

The main product of the reaction between 1‐methyl‐1, 4, 5, 6‐tetrahydronicotin‐amide and ethyl bromoacetate is shown to be the 2‐(1‐methyl‐1, 4, 5, 6‐tetrahydropyridyl‐3)‐2‐oxazoline‐4‐one which on partial hydrogenation followed by reaction with alkali affords O‐(1‐methylnipecotinoyl)glycolic amide, presumably via the tautomeric cyclol.