✦ LIBER ✦

Bilateral renal oncocytomas: Management and nuclear analysis

✍ Scribed by J. Stuart Wolf Jr.; Peter R. Carroll

Book ID: 102437802
Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 435 KB
Volume: 48
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930480411

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✦ Synopsis

Abstract

Only 16 cases of bilateral renal oncocytomas have been previously reported in the English language literature, 9 of which were treated with bilateral surgical resections. We report a case treated with bilateral partial nephrectomy. Although pathological examination revealed grade I oncocytomas on both sides, flow cytometry demonstrated tumor DNA content to be aneuploid on one side and diploid on the other, the first cellular differences reported in a case of bilateral renal oncocytomas. The management of suspected renal oncocytomas is discussed, with emphasis on the need for complete excision in most patients. The results of nuclear studies of these tumors, including DNA flow cytometry, cytogenetics, and molecular analysis of both nuclear and mitochondrial DNA, are reviewed.

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