Effect of intrapatient dosage escalation
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Amar Gajjar; Murali M. Chintagumpala; Daniel C. Bowers; Dana Jones-Wallace; Clin
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Article
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2003
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John Wiley and Sons
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English
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The authors set out to determine the effect of intrapatient dose escalation of irinotecan on its disposition in pediatric patients with high-grade glioma who received concomitant enzyme-inducing anticonvulsants (EIAs). During Course 1, a 60-minute intravenous infusion of irinotecan (20 mg/m(2) per d