𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Bilateral changes in neuronal activity of the basal ganglia in the unilateral 6-hydroxydopamine rat model

✍ Scribed by S. Breit; A. Martin; L. Lessmann; D. Cerkez; T. Gasser; J.B. Schulz

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
354 KB
Volume
86
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The functional significance of the interhemispheric projections on the basal ganglia level is poorly understood. Insofar as the anatomical evidence for crossing projections between basal ganglia nuclei is sparse, whereas tracing studies demonstrated important crossing projections from the pedunculopontine nucleus (PPN) to the basal ganglia, it is suggested that the PPN might play a key role in interhemispheric regulation of basal ganglia activity. The present study was performed to assess changes in neuronal activity of ipsilateral and contralateral subthalamic nucleus (STN), substantia nigra pars reticulata (SNr), and PPN in the unilateral 6‐hydroxydopamine (6‐OHDA) rat model of advanced PD under urethane anesthesia. After unilateral lesioning of the SNc, the firing rate of contralateral STN neurons significantly increased from 10.9 ± 1.0 spikes/sec (mean ± SEM) to 16.3 ± 1.5 spikes/sec. Similarly, the firing rate of contralateral SNr neurons significantly increased from 19.4 ± 1.2 to 25.7 ± 1.9 spikes/sec, and the firing rate of contralateral PPN neurons significantly increased from 10.6 ± 0.8 to 13.9 ± 1.1 spikes/sec. The observed activity changes in contralateral STN, SNr, and PPN are similar to those induced in the corresponding nuclei of the hemisphere ipsilateral to the nigrostriatal degeneration. Based on previous, predominantly anatomical data, the results of the present study suggest that the PPN on the lesioned side is at the origin of changes in the activity of STN and SNr on the contralateral hemisphere, because of its crossing efferent projections. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Progressive degeneration of dopamine neu
Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of parkinson's disease does not involve activation of caspase-9 and caspase-3
✍ Allison D. Ebert; Hoo Jae Hann; Martha C. Bohn 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 233 KB

## Abstract 6‐Hydroxydopamine (6‐OHDA), a neurotoxin that causes the death of dopamine (DA) neurons, is commonly used to produce experimental models of Parkinson's disease (PD) in rodents. In the rat model of PD first described by Sauer and Oertel, DA neurons progressively die over several weeks fo

Riluzole reduces hyperactivity of subtha
Riluzole reduces hyperactivity of subthalamic neurons induced by unilateral 6-OHDA lesion in the rat brain
✍ Oum-Kaltoum Hassani; Mireille Mouroux; Georg Andrees Bohme; Jean-Marie Stutzmann 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 91 KB

## Abstract An abnormal increase in the activity of neurons of the subthalamic nucleus is a key pathophysiological feature of Parkinson's disease. We sought to determine whether riluzole, a sodium channel inhibitor that interferes with glutamatergic neurotransmission, affects neuronal activity in t

Nonmotor symptoms in Parkinson's disease
Nonmotor symptoms in Parkinson's disease: Investigating early-phase onset of behavioral dysfunction in the 6-hydroxydopamine-lesioned rat model
✍ Igor Branchi; Ivana D'Andrea; Monica Armida; Tommaso Cassano; Antonella Pèzzola; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 320 KB 👁 1 views

## Abstract To investigate the psychiatric symptoms accompanying the early phases of Parkinson's disease (PD), we injected adult rats with 10.5 μg 6‐hydroxydopamine (6‐OHDA) bilaterally into the dorsal striatum. The resulting neurodegeneration led, 12 weeks after injection, to a mild (36%) reductio

Altered extracellular striatal in vivo b
Altered extracellular striatal in vivo biotransformation of the opioid neuropeptide dynorphin A(1–17) in the unilateral 6-OHDA rat model of Parkinson's disease
✍ Rebecka Klintenberg; Per E. Andrén 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 226 KB

## Abstract The __in vivo__ biotransformation of dynorphin A(1–17) (Dyn A) was studied in the striatum of hemiparkinsonian rats by using microdialysis in combination with nanoflow reversed‐phase liquid chromatography/electrospray time‐of‐flight mass spectrometry. The microdialysis probes were impla

Role of kainate receptor activation and
Role of kainate receptor activation and desensitization on the [Ca2+]i changes in cultured rat hippocampal neurons
✍ Ana P. Silva; João O. Malva; António F. Ambrósio; António J. Salgado; Arsélio P. 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 293 KB 👁 1 views

We investigated the role of kainate (KA) receptor activation and desensitization in inducing the increase in the intracellular free Ca(2+) concentration ([Ca(2+)](i)) in individual cultured rat hippocampal neurons. The rat hippocampal neurons in the cultures were shown to express kainate receptor su

Erratum: Total number of neurons in the
Erratum: Total number of neurons in the neostriatal, pallidal, subthalamic and substantia nigral nuclei of the rat basal ganglia: A stereological study using the Cavalieri and optical disector methods. J. Comp. Neurol.366:580-N599.
✍ Oorschot, D.E. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 16 KB 👁 2 views

Two errors have appeared in Table 2. For the substantia nigra compacta, the correct real interpoint distance (mm) is 0.1176 mm, not 0.1765 mm, and the correct real area of each point, a(p) (mm 2 ) is 0.0138 mm 2 , not 0.0312 mm 2 . The data in Table 1 for the substantia nigra compacta is based on th