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Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase

✍ Scribed by O. Bourron; M. Daval; I. Hainault; E. Hajduch; J. M. Servant; J. F. Gautier; P. Ferré; F. Foufelle


Publisher
Springer
Year
2009
Tongue
English
Weight
338 KB
Volume
53
Category
Article
ISSN
0012-186X

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## Abstract 8‐Cl‐cAMP (8‐chloro‐cyclic AMP), which induces differentiation, growth inhibition and apoptosis in various cancer cells, has been investigated as a putative anti‐cancer drug. Although we reported that 8‐Cl‐cAMP induces growth inhibition via p38 mitogen‐activated protein kinase (MAPK) an