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Bifurcations and chaos in the MAPK signaling cascade

✍ Scribed by Martin Zumsande; Thilo Gross


Book ID
108196609
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
876 KB
Volume
265
Category
Article
ISSN
0022-5193

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The Ras-MAPK signaling cascade transmits mitogenic stimuli from growth factor receptors and activated Ras to the cell nucleus. Inappropriate Ras activation is associated with approximately 30% of all human cancers. The kinase components of the Ras-MAPK signaling cascade are attractive targets for ph