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Bieyclic bases . Synthesis and stereochemical studies of chiral 5-substituted N-tosyl-2-azabicyclo[2.2.1[ heptanes

โœ Scribed by P. S. Portoghese; D. L. Lattin; V. G. Telang


Book ID
112122542
Publisher
Journal of Heterocyclic Chemistry
Year
1971
Tongue
English
Weight
482 KB
Volume
8
Category
Article
ISSN
0022-152X

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A synthetic route to the epibatidine analogue endo-5-(6-chloro-3-pyridyl)-2-azabicyclo[2.2.1]heptane and the corresponding endo-6-isomer is described, starting from a readily-available 2-azabicyclo[2.2.1]hept-5-ene derivative. Both the exo-5-and exo-6-compounds are also shown to be accessible from t