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Bicyclization of a weak oxytocin agonist produces a highly potent oxytocin antagonist

✍ Scribed by Hill, Patricia S.; Smith, D. David; Slaninova, Jirina; Hruby, Victor J.

Book ID
127086097
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
623 KB
Volume
112
Category
Article
ISSN
0002-7863

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πŸ“œ SIMILAR VOLUMES

Design of novel bicyclic analogues deriv
Design of novel bicyclic analogues derived from a potent oxytocin antagonist
✍ George Flouret; Olivier Chaloin; Lenka Borovickova; Jirina SlaninovΓ‘ πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 133 KB

## Abstract Eleven new analogues were synthesized by modification of the potent oxytocin antagonist (OTA) [(S)Pmp^1^, D‐Trp^2^, Pen^6^, Arg^8^]‐Oxytocin, or PA (parent antagonist), in which (S)Pmp = Ξ²,β‐(3‐thiapentamethylene)‐β‐mercapto‐propionic acid. By internal acylation of Lys, Orn, L‐1,4‐diami