Chiral resolution and molecular modeling
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M.G. Quaglia; A. Mai; G. Sbardella; M. Artico; R. Ragno; S. Massa; D. del Piano;
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Article
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2001
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John Wiley and Sons
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English
⚖ 913 KB
rac-2-Cyclopentylthio-6-[1-(2,6-difluorophenyl)ethyl]-3,4-dihydro-5-methylpyrimidin-4(3H)-one (MC-1047) is a potent inhibitor of HIV-1 multiplication in acutely infected cells. MC-1047 racemate has been resolved by chiral HPLC using, as chiral stationary phase (CSP), a commercially available (R,R)-W