Biconcave coated, centrally perforated tablets for oral controlled drug delivery
โ Scribed by Amal Y. Benkorah; Jean-Norbert McMullen
- Book ID
- 113275700
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 656 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0168-3659
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Tablets with a central hole and a water-impermeable coating were prepared. These perforated coated tablets (PCTs) dissolve and release drug through the central hole only. In vitro release of the model drugs sodium benzoate and benzamide from PCTs occurred at a constant rate up to 80% release. The ze
When used as release-controlling coating agents for tableted core-based pulsatile delivery systems, three different hydroxypropyl methylcellulose (HPMC) grades, Methocel 1 E5, E50, and K4M, provided lag phases of varying duration (Methocel 1 K4M > E50 > E5) and a prompt and quantitative model drug r