𝔖 Bobbio Scriptorium
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Biaryl Synthesis with Control of Axial Chirality

✍ Scribed by Timothy W. Wallace

Publisher
John Wiley and Sons
Year
2007
Weight
11 KB
Volume
38
Category
Article
ISSN
0931-7597

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πŸ“œ SIMILAR VOLUMES

Synthesis of Axially Chiral Biaryls by A
Synthesis of Axially Chiral Biaryls by Atropo-Diastereoselective Cleavage of Configurationally Unstable Biaryl Lactones with Menthol-Derived O-Nucleophiles
✍ Gerhard Bringmann; Matthias Breuning; Rainer Walter; Andreas Wuzik; Karl Peters; πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 480 KB πŸ‘ 1 views

Configurationally unstable lactone-bridged biaryls 4 are 5 possibly formed (if at all) can be recycled ("axially chiral economy") by cyclization back to the lactone 4. For the cleaved atropo-diastereoselectively using chiral mentholderived alkali metal alkoxides, to give axially chiral biaryl prepar