Bi-specific immunomagnetic enrichment of micrometastatic tumour cell clusters from bone marrow of cancer patients
✍ Scribed by Ute Woelfle; Elisabeth Breit; Kristine Zafrakas; Marcus Otte; Falk Schubert; Volkmar Müller; Jakob R. Izbicki; Thomas Löning; Klaus Pantel
- Book ID
- 113716987
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 223 KB
- Volume
- 300
- Category
- Article
- ISSN
- 0022-1759
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## Abstract Disseminated tumor cells (DTC) in bone marrow are independently related to poor outcome in patients with breast cancer. Phenotypic characterization of DTC may be useful to improve evaluation of the metastasizing potential of DTC and also to more accurately target aggressive tumor cells.
Immunocytochemical detection (ICC) of isolated tumor cells in bone marrow (BM) is currently the most established method for monitoring early dissemination in epithelial cancer. However, the low sample size that can practically be analyzed restricts the sensitivity and reliability of the ICC method.