Preparation of opium alkaloids by pallad
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Chang Y. Hong; Larry E. Overman
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Article
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1994
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Elsevier Science
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French
โ 219 KB
Absbxacf. Palladium catalyzed cyclization of hydroisoquinoline dlene 10 to afford the pentacyclic opiate 11 is the central step in a new synthesis of opium alkaloids. We recently described a oew asymmetric synthesis of opium alkaloids in which an intmmoIecular Heck arylation was a central step (e.g.