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Bi-directional plasticity and age-dependent long-term depression at mouse CA3-CA1 hippocampal synapses

โœ Scribed by Austen J Milner; Damian M Cummings; Jonathan P Spencer; Kerry P.S.J Murphy


Book ID
116766747
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
115 KB
Volume
367
Category
Article
ISSN
0304-3940

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## Abstract The induction of longโ€term potentiation (LTP) of CA3โ€CA1 synapses requires activation of postsynaptic __N__โ€methylโ€Dโ€aspartate receptors (GluNRs). At resting potential, the contribution of GluNRs is limited by their voltageโ€dependent block by extracellular Mg^2+^. Highโ€frequency afferen