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Beyond the benzodiazepines: The search for new anxiolytics. A summary of pre-clinical approaches

โœ Scribed by Sandra E. File

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
798 KB
Volume
2
Category
Article
ISSN
0885-6222

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โœฆ Synopsis

The clinical efficacy of the benzodiazepines in reducing anxiety is widely accepted. However, the search for novel anxiolytics continues, motivated by the hope of finding a non-sedative anxiolytic. This article reviews the pre-clinical evidence for new compounds as it relates both to their anxiolytic actions in animal tests and to their sedative potential. Drugs acting at sites on the GABA-benzodiazepine receptor complex are discussed, as well as the potential importance of aminergic and peptidergic pathways.

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