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Bevacizumab with 5-fluorouracil, leucovorin, and oxaliplatin versus bevacizumab with capecitabine and oxaliplatin for metastatic colorectal carcinoma: results of a large registry-based cohort analysis

✍ Scribed by Buchler, Tomas; Pavlik, Tomas; Melichar, Bohuslav; Bortlicek, Zbynek; Usiakova, Zuzana; Dusek, Ladislav; Kiss, Igor; Kohoutek, Milan; Benesova, Vera; Vyzula, Rostislav; Abrahamova, Jitka; Obermannova, Radka

Book ID
125398959
Publisher
BioMed Central
Year
2014
Tongue
English
Weight
185 KB
Volume
14
Category
Article
ISSN
1471-2407

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## BACKGROUND. The combination of 5-fluorouracil (5-FU), leucovorin (LV), and oxaliplatin (l-OHP) was shown to be both more active against metastatic colorectal carcinoma and better tolerated if the drug delivery rate was chronomodulated according to circadian rhythms rather than constant. This all