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Between Scylla and Charybdis: p53 links tumor suppression and aging

✍ Scribed by Judith Campisi

Book ID
114096204
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
77 KB
Volume
123
Category
Article
ISSN
0047-6374

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## Abstract The tumor suppressor p53 has long been known to play a central role in maintaining a stable genome in the face of toxic insults through its role in promoting cell‐cycle checkpoints, DNA repair, and apoptosis. However, p53 null cells still retain some function of certain checkpoint and r