Beta2-GPI: a novel factor in the development of hepatocellular carcinoma
β Scribed by Xue Jing; Yun-Feng Piao; Ye Liu; Pu-Jun Gao
- Publisher
- Springer-Verlag
- Year
- 2010
- Tongue
- English
- Weight
- 734 KB
- Volume
- 136
- Category
- Article
- ISSN
- 1432-1335
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
miR-122 is a highly abundant, hepatocyte-specific microRNA. The biomedical significance and regulatory mechanisms of miR-122 remain obscure. We explored the role of miR-122 in tumorigenesis in the context of gene regulatory network. The miR-122 promoter and its transactivator were identified by way
## Angiogenesis is essential for the development of a solid tumor, including hepatocellular carcinoma (HCC). HCC is a well-known hypervascular tumor. Vascular endothelial growth factor (VEGF) is one of the most potent angiogenic factors. Its role has not been clarified in vivo in HCC development.
The insulin-like growth factor 2 (IGF2) gene is regulated in a complex manner, involving developmentally regulated use of four different promoters as well as transcriptional repression of the maternal allele due to genomic imprinting. It has been well documented that liver is an exceptional organ in