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Beta1-adrenoceptors in rat hepatoma. Desensitization by isoproterenol and phorbol-myristate-acetate

✍ Scribed by J.Adolfo García-Sáinz; Rocío Alcántara; S.M.Teresa Hernández-Sotomayor; Jaime Mas-Oliva


Book ID
118343970
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
460 KB
Volume
44
Category
Article
ISSN
0024-3205

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The transcriptional regulation of the fibronectin (FN) gene in hepatoma cells by phorbol myristate acetate (PMA) was investigated. PMA increased the synthesis and mRNA levels of FN and its promoter activity in Hep3B hepatoma cells. The PMA-induced activation of FN expression was blocked by a protein