Beta-globin haplotypes from blood spots for follow-up of newborn hemoglobinopathy screening
✍ Scribed by Hiti, Alan L.; Zeng, Licheng; Xiang, Qing; Lorey, Fred W.; Powars, Darleen R.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 47 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
The inheritance of sickle-cell anemia upon the background of the major -globin gene cluster haplotypes has been associated with differing risks for major organ failure, and more recently with response to hydroxyurea treatment. Early identification of -globin haplotypes in individuals with sickle-cell anemia may be a clinically useful prognostic factor for severity of disease expression. This report describes the use of whole-blood spots on filter papers from newborn hemoglobinopathy screening for -globin gene cluster haplotyping by the polymerase chain reaction. Am.