Beta catenin and cytokine pathway dysregulation in patients with manifestations of the "PTEN hamartoma tumor syndrome"

Allelic imbalance, including deletion of

Allelic imbalance, including deletion of PTEN/MMAC1, at the Cowden disease locus on 10q22-23, in hamartomas from patients with cowden syndrome and germline PTEN mutation

✍ Debbie J. Marsh; Patricia L. M. Dahia; Valérie Coulon; Zimu Zheng; Françoise Dor 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 174 KB 👁 3 views

Cowden disease (CD) is a rare, autosomal dominant inherited cancer syndrome characterized by multiple benign and malignant lesions in a wide spectrum of tissues. While individuals with CD have an increased risk of breast and thyroid neoplasms, the primary features of CD are hamartomas. The gene for