Beta amyloid peptide: from different aggregation forms to the activation of different biochemical pathways

Solid-state NMR reveals differences in t

Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin

✍ Hannah A. Davies; Jillian Madine; David A. Middleton 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 375 KB

Several polypeptides aggregate into insoluble amyloid fibrils associated with pathologies such as Alzheimer's disease, Parkinson's disease and type 2 diabetes. Understanding the structural and sequential motifs that drive fibrillisation may assist in the discovery and refinement of effective therapi