Beta-2-microglobulin review: Its relevance in clinical oncology

✍ Scribed by Cooper, E. H. ;Plesner, T.

• Book ID: 102949761
• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: English
• Weight: 764 KB
• Volume: 8
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950080403

✦ Synopsis

Abstract

Beta‐2‐microglobulin (β2‐m) is an intrinsic part of the HLA system and is most probably involved in cell recognition. The levels of free β2‐m in the blood and urine are influenced by β2‐m production and its clearance and destruction in the kidney. Many tumors can be associated with an elevated serumβ2‐m, the reason is unknown. The most promising application of β2‐m as a tumor marker would appear to be lymphoid malignancies, especially multiple myeloma and chronic lymphocytic leukemia.