Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats
✍ Scribed by Sarajärvi, Timo; Lipsanen, Anu; Mäkinen, Petra; Peräniemi, Sirpa; Soininen, Hilkka; Haapasalo, Annakaisa; Jolkkonen, Jukka; Hiltunen, Mikko
- Book ID
- 118212970
- Publisher
- Carol Davila University of Medicine Bucharest, Romania
- Year
- 2012
- Tongue
- English
- Weight
- 457 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1582-1838
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## Abstract Mitochondrial dysfunction has been proved to contribute to ischemia‐induced brain damage. In this study, which used a rat middle cerebral artery occlusion (MCAO) model, the protective effects of huperzine A (HupA) against mitochondrial dysfunction and brain damage were investigated. MCA
The goal of this study was to investigate apparent diffusion coefficient (ADC) and T(2) relaxation time (T(2)) in the substantia nigra and thalamus after middle cerebral artery occlusion in rats. In the substantia nigra ipsilateral to infarct, ADC was significantly lower and T(2) was significantly h