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BEPITOPE: predicting the location of continuous epitopes and patterns in proteins

✍ Scribed by Michael Odorico; Jean-Luc Pellequer

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 239 KB
Volume: 16
Category: Article
ISSN: 0952-3499
DOI: 10.1002/jmr.602

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✦ Synopsis

Abstract

In growing need of obtaining highly specific monoclonal antibodies against novel proteins, we developed new functions implemented in the program BEPITOPE to predict continuous protein epitopes. This program not only can compute, combine, display and print prediction profiles, but also provides a list of suggested linear peptides to be synthesized. Novel facilities incorporated in BEPITOPE include the treatment of a whole genome, the search for a user‐defined pattern, and the combination of prediction to pattern profiles. This latter approach is useful to remove unwanted predictions such as those including glycosylation sites. Copyright © 2003 John Wiley & Sons, Ltd.

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