Benzyne-induced ring opening reaction of thiiranes. Efficient synthesis of phenyl vinyl sulfides
โ Scribed by Juzo Nakayama; Satoshi Takeue; Masamatsu Hoshino
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 203 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
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An efficient formal synthesis of balanol is described. The thirteen-step sequence features a highly enantioselective (92% ee) ring opening of 1,4-cyclohexadiane monoepoxide with TMSN~ catalyzed by the Cr-salen complex 3. A selective Beckmann rearrangement followed by amide reduction and nitrogen fun