Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity

✍ Scribed by Ki Hyun Kim; Il Kyun Lee; Cheng Jie Piao; Sang Un Choi; Jei Hyun Lee; Yeong Shik Kim; Kang Ro Lee

• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 208 KB
• Volume: 20
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.06.035

✦ Synopsis

Chemical investigation of the tubers of Corydalis ternata resulted in the isolation and characterization of four new benzylisoquinoline alkaloids, epi-coryximine (1) and coryternatines A-C (2-4), along with 10 known alkaloids (5-14). Their structures were established on the basis of extensive spectroscopic data analyses and comparison with spectroscopic data reported. In addition, the cytotoxicities of the alkaloids (1-14) were evaluated by determining their inhibitory effects on several human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) using the SRB assay. Compound 8 showed significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (IC 50 = 8.34, 5.14, 7.87, and 2.86 lM, respectively). The four new compounds (1-4) exhibited selective cytotoxicity against the HCT-15 cell line.