Benzoylpyruvates in heterocyclic chemistry

✍ Scribed by Jens M. J. Nolsöe; Dirk Weigelt

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2009
• Tongue: English
• Weight: 167 KB
• Volume: 46
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.15

✦ Synopsis

Abstract

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The present review covers the utility of benzoylpyruvates as a vehicle for the preparation of highly functionalized heterocycles. Regio‐ and chemoselective features are discussed with reference to the application of different nucleophilic species. In this context, the preparation of such rings as pyrazoles, isoxazoles, primidines, and pyridines are presented. As the means to establish a distinct functional pattern, the rendered strategy can be seen as an alternative to cross‐coupling protocols. J. Heterocyclic Chem., (2009).