Benzothiazines in organic synthesis. An approach to floresolide B

✍ Scribed by Yugang Chen; Michael Harmata

• Book ID: 104099323
• Publisher: Elsevier Science
• Year: 2011
• Tongue: French
• Weight: 451 KB
• Volume: 52
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2011.05.091

✦ Synopsis

The intramolecular conjugate addition of a sulfoximine carbanion to an α,β-unsaturated ester results in the formation of a benzothiaine bearing a benzylic stereocenter with extremely high fidelity. We have used this methodology to complete a formal total synthesis of the antitumor agent (+)-floresolide B.