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Benzoquinones from Ardisia japonica with Inhibitory Activity towards Human Protein Tyrosine Phosphatase 1B (PTP1B)

✍ Scribed by Yan-Fang Li; Jia Li; Qiang Shen; Li-Hong Hu

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
67 KB
Volume
4
Category
Article
ISSN
1612-1872

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✦ Synopsis

Abstract

From the whole plant of Ardisia japonica, four [1,4]benzoquinones were isolated by means of bioassay‐directed fractionation of the EtOH extract. Apart from the two known compounds maesanin (1) and its congener 2, two new benzoquinones, i.e., 5‐ethoxy‐2‐hydroxy‐3‐[(10__Z__)‐pentadec‐10‐en‐1‐yl][1,4]benzoquinone (3) and 5‐ethoxy‐2‐hydroxy‐3‐[(8__Z__)‐tridec‐8‐en‐1‐yl][1,4]benzoquinone (4), were identified. All compounds showed significant in vitro bioactivities against the PTP1B enzyme, with IC~50~ values in the range of ca. 3–19 μM.

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