✦ LIBER ✦

Benzopyran selective estrogen receptor modulators (SERMs): Pharmacological effects and structural correlation with raloxifene

✍ Scribed by Timothy A. Grese; James P. Sluka; Henry U. Bryant; Harlan W. Cole; John R. Kim; David E. Magee; Ellen R. Rowley; Masahiko Sato

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 314 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00141-2

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✦ Synopsis

Several 2,3-diarylbenzopyrans have been evaluated in an ovariectomized rat model and found to exhibit tissue selective estrogen agonist activity on bone and serum lipid parameters. A structural model that accounts for the pharmacological similarity of these benzopyrans and the benzothiophene SERM, raloxifene, is proposed.

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