✍ Scribed by Halina Kwiecień; E. Baumann
No coin nor oath required. For personal study only.
Novel 1‐(3‐benzofuranyl)‐2‐phcnylethanones 4a‐d have been prepared by acetylation of 2‐alkylbenzo‐furans 2a‐c with phenylacetyl chlorides 3a‐b. The methoxy derivatives 4b‐d have been demethylated to the corresponding phenols 5b‐d with pyridinium hydrochloride. An attempt to obtain the derivatives of 4d and 5a iodinated in the phenyl ring has been undertaken. The novel compounds have been characterized by ir and nmr spectra and their biological activity examined.
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## Abstract 1‐[3‐(2‐Alkylbenzofuranyl)]‐2‐(3,5‐dibromo‐4‐hydroxyphenyl)ethanones 5a,b and 1‐[3‐(2‐alkylbenzofuranyl)‐2‐(3‐bromo‐4‐methoxyphenyl)ethanones 3a,b were readily prepared by selective bromination of hydroxy 1a,b and methoxy 1c,d ethanones, respectively. A successful method of __O__‐alkyla
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract Dehydrogenation of ethyl 3‐methyl‐4‐oxo‐4,5,6,7‐tetrahydrobenzofuran‐2‐carboxylate 1 with 2,2′‐azobi‐sisobutyronitrile and __N__‐bromosuccinimide gave ethyl 4‐hydroxy‐3‐methylbenzofuran‐2‐carboxylate **3**. Reaction of compounds **3–4** with hydrazine hydrate afforded the corresponding