Benzodiazepine associated reversal of the effects of experimental sleep fragmentation

✍ Scribed by Timothy Roehrs; Lori Merlotti; Leon Rosenthal; Thomas Roth

• Book ID: 102860546
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 558 KB
• Volume: 8
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/hup.470080508

✦ Synopsis

Abstract

Thirty‐six healthy young men and women (age 21–35) received 0.00, 0.25, or 0.50 mg triazolam (n = 12 per group) while undergoing experimental sleep fragmentation in which sleep was disrupted by presenting tones to produce brief EEG arousals (without shortening sleep time). The following day subjects' daytime function was assessed using the Multiple Sleep Latency Test and a divided attention performance task. The fragmentation of sleep produced significant disruption of nocturnal sleep and it reduced daytime alertness. Both active drug doses, relative to placebo, reversed the experimentally produced sleep disturbance and they restored daytime alertness.