Benzo[a]pyrene metabolism in human T 47D mammary tumor cells: Evidence for sulfate conjugation and translocation of reactive metabolites across cell membranes

Microspectrofluorimetric study of the ki

Microspectrofluorimetric study of the kinetics of cellular uptake and metabolization of benzo(a)pyrene in human T 47 D mammary tumor cells: evidence for cytochrome P1450 induction

✍ F. Sureau; L. Chinsky; M. Duquesne; A. Laigle; P. Y. Turpin; C. Amirand; J. P. B 📂 Article 📅 1990 🏛 Springer 🌐 English ⚖ 674 KB

The kinetics of penetration, activation and detoxification of benzo(a)pyrene were determined by near U.V. microspectrofluorimetric measurements on single living cells. This technique allows one to monitor the different intracellular fluorescent species present in a subcellular microvolume by using s