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Benzenesulfonyl derivatives of carboxylic acid amides

โœ Scribed by N. P. Aktaev; A. N. Kozlov; G. A. Sokol'skii; I. L. Knunyants


Book ID
112437154
Publisher
Springer
Year
1974
Tongue
English
Weight
258 KB
Volume
23
Category
Article
ISSN
1573-9171

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Enantioselective protonation of amide en
โœ Juliette Martin; Marie-Claire Lasne; Jean-Christophe Plaquevent; Lucette Duhamel ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 126 KB

Enantioselective protonation was applied on amide enolates la and 2a, derived from piperidine-2carboxylic acid. High enantioselectivity was obtained with diamine (+)-3, as chiral source, and in presence of LiBr. Up to 95ยฑ1% ee for amide 1 and >99% for amide 2 were reached. Moreover, (S)-I and (R)-I