✦ LIBER ✦
Benz[cd]indoles. Part III. A New Stereospecific Synthesis of Dihydrolysergic Acid and an Entry to 14-Substituted Derivatives
✍ Scribed by Walter E. Haefliger
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- German
- Weight
- 667 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
A new convenient synthesis of dihydrolysergic acid is described, which allows the preparation of substituted derivatives, especially those with different substitutents in the aromatic ring. Starting from appropriately substituted 5‐nitro‐2‐tetralones, the synthesis leads via a tricyclic isonitrile to the indole‐ring closure as the last step, thus circumventing the troublesome protection/deprotection of the latter.