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Benzaldehyde-derived chloroformates and their application towards the synthesis of methoxyfenozide-N-[(acyloxy)benzyloxy]carbonyl derivatives

✍ Scribed by Mark J Mulvihill; Duyan V Nguyen; Brian MacDougall; Blanca Martinez-Teipel; Rhoda Joseph; James Gallagher; Damian Weaver; Arkady Gusev; KiHo Chung; William Mathis


Book ID
104231692
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
62 KB
Volume
42
Category
Article
ISSN
0040-4039

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Condensation of 2-formylbenzoic acid with a-amino alcohol substrates proceeds with extremely high diaslereoselectivity to produce tricyclic T-lactam pn~lucts. The relative slereochemislxy of the major diasmreoisomer has been determined by X-ray crystal analysis and a mechanism suggested to explain t