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Benign salivary gland tumors: A cytogenetic study of 21 cases

✍ Scribed by Carmo Martins; Isabel Fonseca; Ana Félix; Lúcia Roque; Jorge Soares

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
452 KB
Volume
60
Category
Article
ISSN
0022-4790

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✦ Synopsis

Abstract

Cytogenetic findings of 21 benign salivary gland tumors, including 14 pleomorphic adenomas, 5 Warthin's tumors, 1 myoepithelioma, and 1 cystadenoma, are reported. The present study confirms that pleomorphic adenomas characteristically have highly specific rearrangements involving only a few chromosome regions (3p21, 8q12 and 12q13–15) which suggests their specific role in the mixed tumors genesis. Warthin's tumors also show nonrandom numerical and structural alterations that were concurrent in one of the cases studied. To our knowledge no cytogenetic data are available in myoepitheliomas and cystadenomas. The former reveals a normal karyotype and the latter shows only clonal numerical alterations (gain of chromosomes 2 and 18). © 1995 Wiley‐Liss, Inc.

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