Benign and malignant Epstein-Barr virus-associated B-cell lymphoproliferative diseases
✍ Scribed by Jeffrey I. Cohen
- Book ID
- 117211337
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 92 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1532-8686
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📜 SIMILAR VOLUMES
EBV infects B lymphocytes in vivo and establishes a life-long persistent infection in the host. The latent infection is controlled by EBV-specific MHC class 1-restricted CTL. Immunosuppression reduces CTL activity, and this facilitates outgrowth of EBV+ve B cell lymphoproliferative disease (BLPD). B
## Abstract Epstein–Barr virus (EBV)‐associated B‐cell lymphoproliferative disease may be polyclonal, oligoclonal, or monoclonal. The degree of tumor clonality reflects the disease pathogenesis and may have implications for disease diagnosis, prognosis, and treatment. In this study, specimens of EB