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Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis

✍ Scribed by Eric Blasko; Christopher A. Haskell; Stewart Leung; Giovanna Gualtieri; Meredith Halks-Miller; Mithra Mahmoudi; Megan K. Dennis; Eric R. Prossnitz; William J. Karpus; Richard Horuk


Book ID
113730519
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
817 KB
Volume
214
Category
Article
ISSN
0165-5728

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Both multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), its animal model, involve inflammatory attack on central nervous system (CNS) white matter, leading to demyelination and axonal damage. Changes in astrocytic morphology and function are also prominent features of MS an