Beneficial effects of quetiapine on memory and hippocampal neurogenesis in a transgenic mouse model of Alzheimer's disease
β Scribed by Jue He; Ruiguo Zhang; Yingxin Yu; Shenghua Zhu; Yanbo Zhang; Junhui Wang; Jiming Kong; Xin-Min Li
- Book ID
- 118466465
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 40 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1552-5260
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π SIMILAR VOLUMES
Abnormal subgranular zone (SGZ) neurogenesis is proposed to contribute to Alzheimer's disease (AD)-related decreases in hippocampal function. Our goal was to examine hippocampal neurogenesis in the PDAPP mouse, a model of AD with age-dependent accumulation of amyloid-β€ 42 (Aβ€ 42 )-containing plaques
## Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with senile Ξ²βamyloid (AΞ²) plaques and cognitive decline. Neurogenesis in the adult hippocampus is implicated in regulating learning and memory, and is increased in human postmortem brain of AD patients. Howe