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Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet

✍ Scribed by T. Kusakabe; H. Tanioka; K. Ebihara; M. Hirata; L. Miyamoto; F. Miyanaga; H. Hige; D. Aotani; T. Fujisawa; H. Masuzaki; K. Hosoda; K. Nakao

Publisher: Springer
Year: 2009
Tongue: English
Weight: 194 KB
Volume: 52
Category: Article
ISSN: 0012-186X
DOI: 10.1007/s00125-009-1258-2

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The effects of chronic high sucrose feeding for 1 month on in vivo and in vitro insulin secretion and on in vivo insulin action were studied in rats with non-insulin-dependent diabetes. As compared to the standard diet, the high sucrose diet induced an increase of the in vivo insulin response to an