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Beneficial effect of short-term exposure of human NK cells to IL15/IL12 and IL15/IL18 on cell apoptosis and function

✍ Scribed by Nectaria N. Sotiriadou; Sonia A. Perez; Angelos D. Gritzapis; Louisa G. Mahaira; Maria Salagianni; Constantin N. Baxevanis; Michael Papamichail


Book ID
113526853
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
674 KB
Volume
234
Category
Article
ISSN
0008-8749

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Cytokine regulation of IL-12 receptor Ξ²2
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The biological activities of IL-12 are mediated through a specific, high-affinity receptor composed of IL-12 receptor(R)beta1 and IL-12Rbeta2 subunits that exist primarily on T and NK cells. Remarkably, the expression of IL-12Rbeta2 on CD4(+) T cells in mouse and humans appears to be differentially