Beneficial effect of hyperbaric oxygen on island flaps subjected to secondary venous ischemia
✍ Scribed by Thomas J. Gampper; Feng Zhang; N.F. Mofakhami; Raymond F. Morgan; Randy Amiss; Martin A. Hoard; Michael F. Angel
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 87 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0738-1085
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✦ Synopsis
Abstract
The potential for hyperbaric oxygen therapy (HBO) to decrease the untoward effects of a secondary ischemic event was studied in the rat superficial epigastric flap model. The secondary venous ischemic flap was created by cross‐clamping the vascular pedicles for 2 h. Twenty‐four hours later, the flap was reelevated and the venous pedicle was occluded for 5 h. Thirty‐two rats were divided into three groups. In experimental group 1, animals received HBO treatment immediately prior to the initial flap elevation and ischemia at 2 atmosphere pressures for 90 min. In experimental group 2, the rats underwent a similar course except for a second 90‐min HBO course immediately prior to the secondary venous occlusion. The rats without HBO therapy were used as controls. The results showed that all control flaps were nonviable at 1 week by clinical inspection and fluorescein injection. Complete flap survival occurred in 20% of group 1 flaps and 30.8% of group 2 flaps. Partial flap survival occurred in the rest of the flaps in these two groups, with mean survival areas of 48% and 55%, respectively. In conclusion, HBO treatments significantly increase the survival of flaps subjected to a secondary ischemia, even if administered before the primary ischemia. Administering HBO prior to secondary venous ischemia was marginal, which may be due to the effect of O~2~ given by HBO not lasting longer than 5 h. © 2002 Wiley‐Liss, Inc. MICROSURGERY 22:49–52 2002