Beneficial effect of galectin 9 on rheumatoid arthritis by induction of apoptosis of synovial fibroblasts
β Scribed by Masako Seki; Ken-Mei Sakata; Souichi Oomizu; Tomohiro Arikawa; Atsuko Sakata; Masaki Ueno; Atsuya Nobumoto; Toshiro Niki; Naoki Saita; Kanako Ito; Shu-Yan Dai; Shigeki Katoh; Nozomu Nishi; Michishi Tsukano; Kouichiro Ishikawa; Akira Yamauchi; Vijay Kuchroo; Mitsuomi Hirashima
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 635 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective Rheumatoid arthritis (RA) is characterized by progressive joint destruction. The aim of this study was to clarify the relevance of RA synovial fibroblasts (RASFs) and fibroblast growth factor 2 (FGFβ2), which is produced abundantly by RASFs, to the osteoclastogenesis and b
Objective. B lymphocytes accumulate in the inflamed joints of patients with rheumatoid arthritis (RA) and are responsible for production of high amounts of (auto)-antibodies. The aim of this study was to determine the capacity of fibroblast-like synoviocytes (FLS) to contribute to the accumulation o