Beitrag zur Analytik und Synthese von 3-Hydroxy-4-oxocarotinoiden

✍ Scribed by Robert K. Müller; Kurt Bernhard; Hans Mayer; August Rüttimann; Max Vecchi

• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: German
• Weight: 538 KB
• Volume: 63
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19800630635

✦ Synopsis

Contribution to the Analytical Separation and the Synthesis of 3‐Hydroxy‐4‐oxocarotenoids

(3__RS__,3′RS)‐Astaxanthin (= 3,3′‐dihydroxy‐β,β‐carotene‐4,4′‐dione, 1:1‐mixture of racemate and meso‐form; 1) can be separated into its optical isomers (3__S__,3′S)‐1a, (3__R__,3′R)‐1b and meso‐(3__R__,3′S)‐1c via the corresponding diastereomeric di‐(−)‐camphanates. Some aspects of the configurational stability of astaxanthin are discussed. ‐ HPLC. analysis of the (−)‐camphanates of 3‐hydroxy‐4‐oxocarotenoids provides, in suitable cases and supported by spectroscopic data, an analytical method for the simultaneous determination of constitution and chirality.